Spravato (esketamine) is the only FDA approved nasal spray for adults with treatment resistant depression, which is depression that hasn’t responded adequately to two or more antidepressant medications. Spravato is administered in our REMS-certified treatment center and is covered by most insurance plans. Spravato can help you find hope again when other medications have failed.

What is Spravato® (Esketamine)

Spravato (Esketamine) is the first FDA approved prescription nasal spray for patients whose depressive symptoms persist despite trying two or more medications. Unlike traditional antidepressants that primarily target serotonin, dopamine, and norepinephrine, Spravato is believed to act on the neurotransmitter glutamate, which helps to maintain memory, cognition, and mood regulation. Clinical trials have shown that patients can achieve symptom improvement within 24 hours as opposed to several weeks or months with traditional antidepressant medications. Spravato (Esketamine) is used in combination with oral antidepressant medication, creating a synergistic effect that can assist in shaping more positive and constructive thought patterns. In studies, people who used Spravato with an oral antidepressant reported greater long-term improvement in depression than those who used only oral antidepressants.

Do You Qualify for Spravato® Treatment?

You may be an eligible candidate for Spravato® treatment if you meet the following criteria:

  • Diagnosed with major depressive disorder or treatment-resistant depression.
  • Unresponsive to other forms of treatment like psychotherapy, antidepressant medications, or lifestyle changes.
  • Aged 18 years or older.

If you meet these criteria and want to find out if Spravato® may be right for you, click the link below to schedule your free 10 minute phone consultation, fill out our contact form, or call us at (317) 978-0257.

Spravato® Patient Journey

Schedule your free 10 minute phone consultation to see if Spravato® may be right for you.

Spravato treatment is primarily used for individuals with treatment resistant depression, which means that a patient has tried 2 or more medications and continues to have depressive symptoms.

Taking this step will help us determine if Spravato could be beneficial to your wellness journey.

During your assessment, an IBH provider will perform an in-depth assessment of your medical and psychiatric history and will discuss available treatment options, including Spravato. We do not have a one size fits all approach for mental health care and Spravato may not be right for everyone.

If our provider determines that Spravato may be an effective treatment option for you, they will discuss each phase of the treatment process with you.

Most commercial insurance carriers carry the cost of Spravato, aside from copays, deductibles, and coinsurance. If you are a candidate for Spravato, we will contact your insurance company to determine coverage and cost.

Patients who are deemed clinically appropriate for Spravato treatments may also choose a self-pay option to cover the cost of treatment.

Treatments are provided in our private Spravato suites designed with a spa-like experience in mind. On treatment days, you will self-administer the nasal spray under close observation of our specially trained staff.

After administration you will relax in your suite during a 2-hour observation period where you can sleep, listen to music, watch movies, and rest comfortably in your private suite. If you would like, it is perfectly fine for a friend or a family member to stay with you during treatment.

Because of possible side effects affecting mental alertness and motor coordination, patients will need to plan for rides to and from our center on treatment days.

Common Questions about Spravato

Most people experience mild sedation, dissociation, and increase in blood pressure. Some people may experience nausea or headache. The side effects typically peak at 40 minutes after the first dose and resolve by the end of the 2 hour monitoring period. Because Spravato can cause sedation, you will not be able to drive until you’ve had a restful night’s sleep.

Cost for Spravato depends on insurance coverage. Please see our insurance page for more information.

While other oral antidepressant medications work on serotonin, norepinephrine, or dopamine, Spravato is different because it acts on a neurotransmitter called glutamate. Glutamate helps to regulate emotions and can improve motivation and memory. Since it is one of the most plentiful neurotransmitters in the brain, esketamine can impact more brain cells at the same time, leading to symptom improvement more quickly than oral antidepressants. Some people see improvement in depressive symptoms within days or hours.

Spravato is administered in a REMS-certified treatment center. The typical treatment schedule is:

  • Twice weekly for 4 weeks, then
  • Once weekly for 4 weeks, then
  • Every other week
Your treatment center will talk with you every 4 weeks to determine how well Spravato is working for you and whether you would benefit from treatments more or less often.

Spravato is a treatment for depression that is used long-term in addition to an oral antidepressant medication.

We are in network with most major insurance companies